671
edits
Sandbox: Difference between revisions
no edit summary
Jelledejong (talk | contribs) No edit summary |
Jelledejong (talk | contribs) No edit summary |
||
| Line 71: | Line 71: | ||
==Treatment== | ==Treatment== | ||
Cardiac pacing is the therapy of choice in syncope patients with documented asystole (>3 s) in response to carotid sinus massage, or on ambulatory ECG recording (Kenny et al., 2001). The vasodepressor type is likely to benefit from general orthostatic tolerance enhancing measures such as salt and volume loading, and there is some evidence that fludrocortisone may be effective (Hussain et al., 1996). However up to date there are no large scale clinical trials confirming this. | Cardiac pacing is the therapy of choice in syncope patients with documented asystole (>3 s) in response to carotid sinus massage, or on ambulatory ECG recording (Kenny et al., 2001). The vasodepressor type is likely to benefit from general orthostatic tolerance enhancing measures such as salt and volume loading, and there is some evidence that fludrocortisone may be effective (Hussain et al., 1996). However up to date there are no large scale clinical trials confirming this. | ||
=Swallow Syncope= | |||
Swallow syncope incorporates two separate conditions: | |||
# a pharyngeal form which is usually associated with pain (“syncopal glossopharyneal neuralgia”) | |||
# an oesophageal variety, also known as “oesophageal” or “deglutition syncope” (fig. 7)(Basker & Cooper, 2000). | |||
The first isolated case description dates to 1906 (Mackenzie, 1906). Based on the fact that up to date there are only about sixty single cases reported (DEUCHAR & TROUNCE, 1960;Basker & Cooper, 2000), swallow syncope is probably rare. | |||
The clinical presentation of '''glossopharyngeal neuralgia''' is a patient with (seemingly) spontaneous overwhelming pain in a jaw, tongue or throat. In some patients this pain can be triggered by touching a certain spot in the oral cavity, or by talking or swallowing. Among all patients with glossopharyngeal neuralgia, syncope seems a rare complication (Rushton et al., 1981). | |||
In the '''oesophageal variety syncope''' typically occurs during or shortly after swallowing. Several reports point especially to cold drinks as the culprit (Rainford, 1975;Brick et al., 1978;Olshansky, 1999). Syncope triggered by belching has been reported (Kim et al., 2005).There are some that report that mention retro-sternal pain induced by swallowing as a trigger. Several cases report oesophageal syncope during recovery from myocardial infarction. Swallowing syncope is characterised by a slow or absent pulse. | |||
==Pathophysiology== | |||
The pathophysiology of both entities is poorly understood. The possible neurological pathways and mechanisms that might be involved in swallow syncope cannot be explained on the basis of any known normal reflex (Basker & Cooper, 2000). Oesophageal syncope is often ascribed to a vagovagal reflex (i.e. both afferent and efferent stimulus through the vagus nerve)(Piek et al., 1988); however this merely describes part of the peripheral functional anatomy. | |||
In many cases of oesophageal syncope functional, endoscopic and radiological studies reveal oesophageal abnormalities including diverticulum, hiatal hernia, achalasia, stricture and neoplasms (Basker & Cooper, 2000). Although such co-morbidity may be over-reported, in the total clinical picture these case reports may be an argument to commence an in depth gastro-oesophageal evaluation. | |||
==Treatment== | |||
There are several therapeutic options. | |||
# First, in case of overt oesophageal lesions, these should be treated. | |||
# Secondly, if feasible, modification of antihypertensive drugs should be considered. | |||
Surgical or pharmacological destruction of (the oesophageal branches of) the vagus nerve has shown not to be successful. Based on predominantly positive therapeutic response in over a dozen cases, the treatment of choice of oesophageal syncope is insertion of a cardiac demand pacemaker (Basker & Cooper, 2000). Management of persisting neuralgia is symptomatic. | |||